Genetic Variability in Key Genes in Prostaglandin E(2) Pathway (COX-2, HPGD, ABCC4 and SLCO2A1) and Their Involvement in Colorectal Cancer Development

The pro-carcinogenic effects of prostaglandin E2 (PGE(2)) in colonic mucosa are not only regulated by the rates between Cyclooxygenase-2 (COX-2) biosynthesis and 15-Hydroxyprostaglandin Dehydrogenase (15-PGDH)-dependent degradation but also the steady-state levels of PGE(2) in extracellular microenv...

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Detalhes bibliográficos
Main Authors: Pereira, Carina, Queirós, Sara, Galaghar, Ana, Sousa, Hugo, Pimentel-Nunes, Pedro, Brandão, Catarina, Moreira-Dias, Luís, Medeiros, Rui, Dinis-Ribeiro, Mário
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2014
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3973663/
https://ncbi.nlm.nih.gov/pubmed/24694755
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0092000
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