Feedback loops blockade potentiates apoptosis induction and antitumor activity of a novel AKT inhibitor DC120 in human liver cancer

The serine/threonine kinase AKT is generally accepted as a promising anticancer therapeutic target. However, the relief of feedback inhibition and enhancement of other survival pathways often attenuate the anticancer effects of AKT inhibitors. These compensatory mechanisms are very complicated and r...

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Detalles Bibliográficos
Main Authors: Yang, F, Deng, R, Qian, X-J, Chang, S-H, Wu, X-Q, Qin, J, Feng, G-K, Ding, K, Zhu, X-F
Formato: Artigo
Idioma:Inglês
Publicado: Nature Publishing Group 2014
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Original Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3973233/
https://ncbi.nlm.nih.gov/pubmed/24625973
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2014.43
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