Longikaurin A, a natural ent-kaurane, induces G2/M phase arrest via downregulation of Skp2 and apoptosis induction through ROS/JNK/c-Jun pathway in hepatocellular carcinoma cells

Hepatocellular carcinoma (HCC) is the most common form of primary liver cancer, and is also highly resistant to conventional chemotherapy treatments. In this study, we report that Longikaurin A (LK-A), an ent-kaurane diterpenoid isolated from the plant Isodon ternifolius, induced cell cycle arrest a...

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Bibliographische Detailangaben
Hauptverfasser: Liao, Y-J, Bai, H-Y, Li, Z-H, Zou, J, Chen, J-W, Zheng, F, Zhang, J-X, Mai, S-J, Zeng, M-S, Sun, H-D, Pu, J-X, Xie, D
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group 2014
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Original Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3973226/
https://ncbi.nlm.nih.gov/pubmed/24651440
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2014.66
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