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p53 induces skin aging by depleting Blimp1(+) sebaceous gland cells

p53 is an important inducer of organismal aging. However, its roles in the aging of skin remain unclear. Here we show that mice with chronic activation of p53 develop an aging phenotype in the skin associated with a reduction of subcutaneous fat and loss of sebaceous gland (SG). The reduction in the...

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Detalhes bibliográficos
Main Authors: Kim, J, Nakasaki, M, Todorova, D, Lake, B, Yuan, C-Y, Jamora, C, Xu, Y
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3973209/
https://ncbi.nlm.nih.gov/pubmed/24675459
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2014.87
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