P42 Ebp1 regulates the proteasomal degradation of the p85 regulatory subunit of PI3K by recruiting a chaperone-E3 ligase complex HSP70/CHIP

The short isoform of ErbB3-binding protein 1 (Ebp1), p42, is considered to be a potent tumor suppressor in a number of human cancers, although the mechanism by which it exerts this tumor-suppressive activity is unclear. Here, we report that p42 interacts with the cSH2 domain of the p85 subunit of ph...

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Main Authors: Ko, H R, Kim, C K, Lee, S B, Song, J, Lee, K-H, Kim, K K, Park, K W, Cho, S-W, Ahn, J-Y
Formato: Artigo
Idioma:Inglês
Publicado: Nature Publishing Group 2014
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Original Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3973206/
https://ncbi.nlm.nih.gov/pubmed/24651434
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2014.79
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