P42 Ebp1 regulates the proteasomal degradation of the p85 regulatory subunit of PI3K by recruiting a chaperone-E3 ligase complex HSP70/CHIP

The short isoform of ErbB3-binding protein 1 (Ebp1), p42, is considered to be a potent tumor suppressor in a number of human cancers, although the mechanism by which it exerts this tumor-suppressive activity is unclear. Here, we report that p42 interacts with the cSH2 domain of the p85 subunit of ph...

詳細記述

保存先:
書誌詳細
主要な著者: Ko, H R, Kim, C K, Lee, S B, Song, J, Lee, K-H, Kim, K K, Park, K W, Cho, S-W, Ahn, J-Y
フォーマット: Artigo
言語:Inglês
出版事項: Nature Publishing Group 2014
主題:
Original Article
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC3973206/
https://ncbi.nlm.nih.gov/pubmed/24651434
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2014.79
タグ: タグ追加
タグなし, このレコードへの初めてのタグを付けませんか!

類似資料