MicroRNA-23a/b and microRNA-27a/b suppress Apaf-1 protein and alleviate hypoxia-induced neuronal apoptosis

Expression of apoptotic protease activating factor-1 (Apaf-1) gradually decreases during brain development, and this decrease is likely responsible for the decreased sensitivity of brain tissue to apoptosis. However, the mechanism by which Apaf-1 expression is decreased remains elusive. In the prese...

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Detalhes bibliográficos
Main Authors: Chen, Q, Xu, J, Li, L, Li, H, Mao, S, Zhang, F, Zen, K, Zhang, C-Y, Zhang, Q
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2014
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3973202/
https://ncbi.nlm.nih.gov/pubmed/24651435
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2014.92
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