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Meformin action in human hepatocytes. Co-activation of atypical protein kinase C alters 5′-AMP-activated protein kinase effects on lipogenic and gluconeogenic enzyme expression
AIMS/HYPOTHESIS: Levels and activity of atypical protein kinase C (aPKC) are elevated in hepatocytes of type 2 diabetic (T2DM) humans and cause excessive increases in expression of lipogenic and gluconeogenic enzymes; aPKC inhibitors largely correct these aberrations. Metformin improves hepatic gluc...
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| Main Authors: | , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2013
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3973184/ https://ncbi.nlm.nih.gov/pubmed/23933835 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00125-013-3010-1 |
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