An autoreactive antibody from an SLE/HIV-1 individual broadly neutralizes HIV-1

Broadly HIV-1–neutralizing antibodies (BnAbs) display one or more unusual traits, including a long heavy chain complementarity-determining region 3 (HCDR3), polyreactivity, and high levels of somatic mutations. These shared characteristics suggest that BnAb development might be limited by immune tol...

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Detalhes bibliográficos
Main Authors: Bonsignori, Mattia, Wiehe, Kevin, Grimm, Sebastian K., Lynch, Rebecca, Yang, Guang, Kozink, Daniel M., Perrin, Florence, Cooper, Abby J., Hwang, Kwan-Ki, Chen, Xi, Liu, Mengfei, McKee, Krisha, Parks, Robert J., Eudailey, Joshua, Wang, Minyue, Clowse, Megan, Criscione-Schreiber, Lisa G., Moody, M. Anthony, Ackerman, Margaret E., Boyd, Scott D., Gao, Feng, Kelsoe, Garnett, Verkoczy, Laurent, Tomaras, Georgia D., Liao, Hua-Xin, Kepler, Thomas B., Montefiori, David C., Mascola, John R., Haynes, Barton F.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2014
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3973118/
https://ncbi.nlm.nih.gov/pubmed/24614107
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI73441
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