Randomized trial of the anti-FGF23 antibody KRN23 in X-linked hypophosphatemia

Background. X-linked hypophosphatemia (XLH) is the most common heritable form of rickets and osteomalacia. XLH-associated mutations in phosphate-regulating endopeptidase (PHEX) result in elevated serum FGF23, decreased renal phosphate reabsorption, and low serum concentrations of phosphate (inorgani...

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Bibliographic Details
Main Authors: Carpenter, Thomas O., Imel, Erik A., Ruppe, Mary D., Weber, Thomas J., Klausner, Mark A., Wooddell, Margaret M., Kawakami, Tetsuyoshi, Ito, Takahiro, Zhang, Xiaoping, Humphrey, Jeffrey, Insogna, Karl L., Peacock, Munro
Format: Artigo
Language:Inglês
Published: American Society for Clinical Investigation 2014
Subjects:
Clinical Medicine
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3973088/
https://ncbi.nlm.nih.gov/pubmed/24569459
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI72829
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