Randomized trial of the anti-FGF23 antibody KRN23 in X-linked hypophosphatemia

Background. X-linked hypophosphatemia (XLH) is the most common heritable form of rickets and osteomalacia. XLH-associated mutations in phosphate-regulating endopeptidase (PHEX) result in elevated serum FGF23, decreased renal phosphate reabsorption, and low serum concentrations of phosphate (inorgani...

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Autors principals: Carpenter, Thomas O., Imel, Erik A., Ruppe, Mary D., Weber, Thomas J., Klausner, Mark A., Wooddell, Margaret M., Kawakami, Tetsuyoshi, Ito, Takahiro, Zhang, Xiaoping, Humphrey, Jeffrey, Insogna, Karl L., Peacock, Munro
Format: Artigo
Idioma:Inglês
Publicat: American Society for Clinical Investigation 2014
Matèries:
Clinical Medicine
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3973088/
https://ncbi.nlm.nih.gov/pubmed/24569459
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI72829
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