Randomized trial of the anti-FGF23 antibody KRN23 in X-linked hypophosphatemia

Background. X-linked hypophosphatemia (XLH) is the most common heritable form of rickets and osteomalacia. XLH-associated mutations in phosphate-regulating endopeptidase (PHEX) result in elevated serum FGF23, decreased renal phosphate reabsorption, and low serum concentrations of phosphate (inorgani...

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Detalhes bibliográficos
Main Authors: Carpenter, Thomas O., Imel, Erik A., Ruppe, Mary D., Weber, Thomas J., Klausner, Mark A., Wooddell, Margaret M., Kawakami, Tetsuyoshi, Ito, Takahiro, Zhang, Xiaoping, Humphrey, Jeffrey, Insogna, Karl L., Peacock, Munro
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2014
Assuntos:
Clinical Medicine
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3973088/
https://ncbi.nlm.nih.gov/pubmed/24569459
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI72829
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