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Familial Alzheimer’s disease–associated presenilin-1 alters cerebellar activity and calcium homeostasis
Familial Alzheimer’s disease (FAD) is characterized by autosomal dominant heritability and early disease onset. Mutations in the gene encoding presenilin-1 (PS1) are found in approximately 80% of cases of FAD, with some of these patients presenting cerebellar damage with amyloid plaques and ataxia w...
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Main Authors: | , , , , , , , , , , , , , , , |
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Formato: | Artigo |
Idioma: | Inglês |
Publicado em: |
American Society for Clinical Investigation
2014
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Assuntos: | |
Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3973081/ https://ncbi.nlm.nih.gov/pubmed/24569455 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI66407 |
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