Tibetans living at sea level have a hyporesponsive hypoxia-inducible factor system and blunted physiological responses to hypoxia

Tibetan natives have lived on the Tibetan plateau (altitude ∼4,000 m) for at least 25,000 years, and as such they are adapted to life and reproduction in a hypoxic environment. Recent studies have identified two genetic loci, EGLN1 and EPAS1, that have undergone natural selection in Tibetans, and fu...

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Huvudupphovsmän: Petousi, Nayia, Croft, Quentin P. P., Cavalleri, Gianpiero L., Cheng, Hung-Yuan, Formenti, Federico, Ishida, Koji, Lunn, Daniel, McCormack, Mark, Shianna, Kevin V., Talbot, Nick P., Ratcliffe, Peter J., Robbins, Peter A.
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Physiological Society 2013
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Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3972739/
https://ncbi.nlm.nih.gov/pubmed/24030663
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/japplphysiol.00535.2013
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