Bone morphogenetic protein-9 suppresses growth of myeloma cells by signaling through ALK2 but is inhibited by endoglin

Multiple myeloma is a malignancy of plasma cells predominantly located in the bone marrow. A number of bone morphogenetic proteins (BMPs) induce apoptosis in myeloma cells in vitro, and with this study we add BMP-9 to the list. BMP-9 has been found in human serum at concentrations that inhibit cance...

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Autors principals: Olsen, O E, Wader, K F, Misund, K, Våtsveen, T K, Rø, T B, Mylin, A K, Turesson, I, Størdal, B F, Moen, S H, Standal, T, Waage, A, Sundan, A, Holien, T
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 2014
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Original Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3972702/
https://ncbi.nlm.nih.gov/pubmed/24658374
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/bcj.2014.16
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