CD123 targeting oncolytic adenoviruses suppress acute myeloid leukemia cell proliferation in vitro and in vivo

We report here a novel strategy to redirect oncolytic adenoviruses to CD123 by carry a soluble coxsackie-adenovirus receptor (sCAR)-IL3 expression cassette in the viral genome to form Ad.IL3, which sustainably infected acute myeloid leukemia (AML) cells through CD123. Ad.IL3 was further engineered t...

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Detalhes bibliográficos
Main Authors: Li, G, Li, X, Wu, H, Yang, X, Zhang, Y, Chen, L, Wu, X, Cui, L, Wu, L, Luo, J, Liu, X Y
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2014
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3972701/
https://ncbi.nlm.nih.gov/pubmed/24658372
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/bcj.2014.15
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