Endothelial Cell-Specific LKB1 Deletion Causes Endothelial Dysfunction and Hypertension in Mice in vivo

BACKGROUND: Liver kinase B1 (LKB1), a tumor suppressor, is a central regulator of cell polarity and energy homeostasis. The role of LKB1 in endothelial function in vivo has not been explored. METHODS AND RESULTS: Endothelium-specific LKB1 knockout (LKB1(endo)(−/−)) mice were generated by crossbreedi...

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Main Authors: Zhang, Wencheng, Wang, Qilong, Wu, Yue, Moriasi, Cate, Liu, Zhaoyu, Dai, Xiaoyan, Wang, Qiongxin, Liu, Weimin, Yuan, Zu-Yi, Zou, Ming-Hui
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3972325/
https://ncbi.nlm.nih.gov/pubmed/24637557
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCULATIONAHA.113.004146
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