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Broken nuclei – lamins, nuclear mechanics and disease
Mutations in lamins, which are ubiquitous nuclear intermediate filaments, lead to a variety of disorders, including muscular dystrophy and dilated cardiomyopathy. Lamins provide nuclear stability, help connect the nucleus to the cytoskeleton, and can modulate chromatin organization and gene expressi...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3972295/ https://ncbi.nlm.nih.gov/pubmed/24309562 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.tcb.2013.11.004 |
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