Gain of ALK Gene Copy Number May Predict Lack of Benefit from Anti-EGFR Treatment in Patients with Advanced Colorectal Cancer and RAS-RAF-PI3KCA Wild-Type Status

INTRODUCTION: Although cetuximab and panitumumab show an increased efficacy for patients with KRAS-NRAS-BRAF and PI3KCA wild-type metastatic colorectal cancer, primary resistance occurs in a relevant subset of molecularly enriched populations. PATIENTS AND METHODS: We evaluated the outcome of 68 pat...

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Detalhes bibliográficos
Main Authors: Pietrantonio, Filippo, Maggi, Claudia, Di Bartolomeo, Maria, Facciorusso, Maria Grazia, Perrone, Federica, Testi, Adele, Iacovelli, Roberto, Miceli, Rosalba, Bossi, Ilaria, Leone, Giorgia, Milione, Massimo, Pelosi, Giuseppe, de Braud, Filippo
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2014
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3972159/
https://ncbi.nlm.nih.gov/pubmed/24691006
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0092147
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