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Using Linkage Analysis to Detect Gene-Gene Interaction by Stratifying Family Data on Known Disease, or Disease-Associated, Alleles

Detecting gene-gene interaction in complex diseases is a major challenge for common disease genetics. Most interaction detection approaches use disease-marker associations and such methods have low power and unknown reliability in real data. We developed and tested a powerful linkage-analysis-based...

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Detalhes bibliográficos
Main Authors: Corso, Barbara, Greenberg, David A.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3972093/
https://ncbi.nlm.nih.gov/pubmed/24690899
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0093398
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