HER2 Dimerization Inhibitor Pertuzumab – Mode of Action and Clinical Data in Breast Cancer

The humanized monoclonal antibody pertuzumab prevents the dimerization of HER2 with other HER receptors, in particular the pairing of the most potent signaling heterodimer HER2/HER3, thus providing a potent strategy for dual HER2 inhibition. It binds to the extracellular domain of HER2 at a differen...

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Detalhes bibliográficos
Main Authors: Harbeck, Nadia, Beckmann, Matthias W., Rody, Achim, Schneeweiss, Andreas, Müller, Volkmar, Fehm, Tanja, Marschner, Norbert, Gluz, Oleg, Schrader, Iris, Heinrich, Georg, Untch, Michael, Jackisch, Christian
Formato: Artigo
Idioma:Inglês
Publicado em: S. Karger GmbH 2013
Assuntos:
Review Article · Übersichtsarbeit
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3971793/
https://ncbi.nlm.nih.gov/pubmed/24715843
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1159/000346837
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