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Current Concepts in Pediatric Philadelphia Chromosome-Positive Acute Lymphoblastic Leukemia
The t(9;22)(q34;q11) or Philadelphia chromosome creates a BCR–ABL1 fusion gene encoding for a chimeric BCR–ABL1 protein. It is present in 3–4% of pediatric acute lymphoblastic leukemia (Ph(+) ALL), and about 25% of adult ALL cases. Prior to the advent of tyrosine kinase inhibitors (TKI), Ph(+) ALL w...
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| Autori principali: | , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Frontiers Media S.A.
2014
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3971203/ https://ncbi.nlm.nih.gov/pubmed/24724051 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fonc.2014.00054 |
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