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Why methylation is not a marker predictive of response to hypomethylating agents
The azanucleotides azacitidine and decitabine have been shown to induce hematologic response and prolong survival in higher-risk myelodysplastic syndromes. They are inhibitors of DNA methyltransferase-1 and induce DNA-hypomethylation. Induction of apoptosis is also clinically relevant, in particular...
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| Main Authors: | , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
Ferrata Storti Foundation
2014
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3971070/ https://ncbi.nlm.nih.gov/pubmed/24688109 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3324/haematol.2013.099549 |
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