In situ enzymatic reclosure of opened imidazole rings of purines in DNA damaged by gamma-irradiation.
When aqueous solutions of DNA were treated with 10-500 grays of gamma-rays, the imidazole rings of some adenine and guanine residues underwent scission, resulting in the conversion of these purines to formamidopyrimidines. It was found that formamidopyrimidine-DNA glycosylase, known to remove imidaz...
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| Udgivet i: | Proc Natl Acad Sci U S A |
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| Principais autores: | , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
National Academy of Sciences
1985
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC397099/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/3856219/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.82.3.633 |
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