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Synergistic activity between the delta-opioid agonist SNC80 and amphetamine occurs via a glutamatergic NMDA-receptor dependent mechanism

Glutamate is known to cause the release of dopamine through a Ca(2+)-sensitive mechanism that involves activation of NMDA ionotropic glutamate receptors. In the current study, we tested the hypothesis that the delta opioid agonist SNC80 acts indirectly, via the glutamatergic system, to enhance both...

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Autors principals: Bosse, Kelly E., Jutkiewicz, Emily M., Schultz, Kristin N., Mabrouk, Omar S., Kennedy, Robert T., Gnegy, Margaret E., Traynor, John R.
Format: Artigo
Idioma:Inglês
Publicat: 2013
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3970824/
https://ncbi.nlm.nih.gov/pubmed/24035916
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuropharm.2013.08.027
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