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Criticality and degeneracy in injury-induced changes in primary afferent excitability and the implications for neuropathic pain
Neuropathic pain remains notoriously difficult to treat despite numerous drug targets. Here, we offer a novel explanation for this intractability. Computer simulations predicted that qualitative changes in primary afferent excitability linked to neuropathic pain arise through a switch in spike initi...
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| Główni autorzy: | , , , |
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| Format: | Artigo |
| Język: | Inglês |
| Wydane: |
eLife Sciences Publications, Ltd
2014
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| Hasła przedmiotowe: | |
| Dostęp online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3970756/ https://ncbi.nlm.nih.gov/pubmed/24692450 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.02370 |
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