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N-WASP-directed actin polymerization activates Cas phosphorylation and lamellipodium spreading

Tyrosine phosphorylation of the substrate domain of Cas (CasSD) correlates with increased cell migration in healthy and diseased cells. Here, we address the mechanism leading to the phosphorylation of CasSD in the context of fibronectin-induced early spreading of fibroblasts. We have previously demo...

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Bibliografische gegevens
Hoofdauteurs: Zhang, Xian, Moore, Simon W., Iskratsch, Thomas, Sheetz, Michael P.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: The Company of Biologists 2014
Onderwerpen:
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3970555/
https://ncbi.nlm.nih.gov/pubmed/24481817
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/jcs.134692
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