Glucose increases the synthesis of lipoxygenase-mediated metabolites of arachidonic acid in intact rat islets.
Previous studies suggested that products of a 12-lipoxygenase pathway in the pancreatic islet may promote insulin release. To determine whether glucose augments the production of such metabolites, intact rat islets prelabeled with [3H]arachidonate were stimulated with glucose, and 12-hydroxy-5,8,10,...
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| Udgivet i: | Proc Natl Acad Sci U S A |
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| Hovedforfatter: | |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
National Academy of Sciences
1985
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC396999/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/3918302/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.82.1.198 |
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