A mammalian adaptor protein with conserved Src homology 2 and phosphotyrosine-binding domains is related to Shc and is specifically expressed in the brain.

The Shc adaptor protein, hereafter referred to as ShcA, possesses two distinct phosphotyrosine-recognition modules, a C-terminal Src homology 2 (SH2) domain and an N-terminal phosphotyrosine-binding (PTB) domain, and is itself phosphorylated on tyrosine in response to many extracellular signals. Pho...

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Publié dans:	Proc Natl Acad Sci U S A
Auteurs principaux:	O'Bryan, J P, Songyang, Z, Cantley, L, Der, C J, Pawson, T
Format:	Artigo
Langue:	Inglês
Publié:	National Academy of Sciences 1996
Sujets:	Research Article
Accès en ligne:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC39699/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8610109/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.93.7.2729
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