Induction of Colonic Regulatory T Cells by Indigenous Clostridium Species

CD4(+) T regulatory cells (T(regs)), which express the Foxp3 transcription factor, play a critical role in the maintenance of immune homeostasis. Here, we show that in mice, T(regs) were most abundant in the colonic mucosa. The spore-forming component of indigenous intestinal microbiota, particularl...

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Autors principals: Atarashi, Koji, Tanoue, Takeshi, Shima, Tatsuichiro, Imaoka, Akemi, Kuwahara, Tomomi, Momose, Yoshika, Cheng, Genhong, Yamasaki, Sho, Saito, Takashi, Ohba, Yusuke, Taniguchi, Tadatsugu, Takeda, Kiyoshi, Hori, Shohei, Ivanov, Ivaylo I., Umesaki, Yoshinori, Itoh, Kikuji, Honda, Kenya
Format: Artigo
Idioma:Inglês
Publicat: 2010
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3969237/
https://ncbi.nlm.nih.gov/pubmed/21205640
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1198469
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