A Phase 1 Study of Everolimus Plus Docetaxel Plus Cisplatin as Induction Chemotherapy for Patients With Locally and/or Regionally Advanced Head and Neck Cancer

BACKGROUND: Activation of the phosphatidylinositol-3-kinase (PI3K)/Akt/mammalian target of rapamycin (mTOR) pathway is common in head and neck cancers, and it has been demonstrated that inhibition of mTOR complex 1 sensitizes cell lines to platinum and taxane chemotherapy. The authors conducted a ph...

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Detalhes bibliográficos
Main Authors: Matthew G., Fury, Sherman, Eric, Ho, Alan L., Xiao, Han, Tsai, Frank, Oby, Nwankwo, Sima, Camelia, Heguy, Adrian, Katabi, Nora, Haque, Sofia, Pfister, David G.
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3969235/
https://ncbi.nlm.nih.gov/pubmed/23408298
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cncr.27986
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