AAV-Mediated Lysophosphatidylcholine Acyltransferase 1 (Lpcat1) Gene Replacement Therapy Rescues Retinal Degeneration in rd11 Mice

PURPOSE. The retinal degeneration 11 (rd11) mouse is a newly discovered, naturally occurring animal model with early photoreceptor dysfunction and rapid rod photoreceptor degeneration followed by cone degeneration. The rd11 mice carry a spontaneous mutation in the lysophosphatidylcholine acyltransfe...

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Main Authors: Dai, Xufeng, Han, Juanjuan, Qi, Yan, Zhang, Hua, Xiang, Lue, Lv, Jineng, Li, Jie, Deng, Wen-Tao, Chang, Bo, Hauswirth, William W., Pang, Ji-jing
格式: Artigo
語言:Inglês
出版: The Association for Research in Vision and Ophthalmology 2014
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Articles
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3968931/
https://ncbi.nlm.nih.gov/pubmed/24557352
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1167/iovs.13-13654
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