The addition of sirolimus to tacrolimus/methotrexate GVHD prophylaxis in children with ALL: a phase 3 Children’s Oncology Group/Pediatric Blood and Marrow Transplant Consortium trial

Sirolimus has activity against acute lymphoblastic leukemia (ALL) in xenograft models and efficacy in preventing acute graft-versus-host disease (aGVHD). We tested whether addition of sirolimus to GVHD prophylaxis of children with ALL would decrease aGVHD and relapse. Patients were randomized to tac...

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Enregistré dans:
Détails bibliographiques
Auteurs principaux: Pulsipher, Michael A., Langholz, Bryan, Wall, Donna A., Schultz, Kirk R., Bunin, Nancy, Carroll, William L., Raetz, Elizabeth, Gardner, Sharon, Gastier-Foster, Julie M., Howrie, Denise, Goyal, Rakesh K., Douglas, James G., Borowitz, Michael, Barnes, Yvonne, Teachey, David T., Taylor, Candace, Grupp, Stephan A.
Format: Artigo
Langue:Inglês
Publié: American Society of Hematology 2014
Sujets:
Clinical Trials and Observations
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3968388/
https://ncbi.nlm.nih.gov/pubmed/24497539
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2013-10-534297
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