Identification of an LGP2-associated MDA5 agonist in picornavirus-infected cells

The RIG-I-like receptors RIG-I, LGP2, and MDA5 initiate an antiviral response that includes production of type I interferons (IFNs). The nature of the RNAs that trigger MDA5 activation in infected cells remains unclear. Here, we purify and characterise LGP2/RNA complexes from cells infected with enc...

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Autori principali: Deddouche, Safia, Goubau, Delphine, Rehwinkel, Jan, Chakravarty, Probir, Begum, Sharmin, Maillard, Pierre V, Borg, Annabel, Matthews, Nik, Feng, Qian, van Kuppeveld, Frank J M, Reis e Sousa, Caetano
Natura: Artigo
Lingua:Inglês
Pubblicazione: eLife Sciences Publications, Ltd 2014
Soggetti:
Immunology
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3967861/
https://ncbi.nlm.nih.gov/pubmed/24550253
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.01535
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