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Lithium induces microcysts and polyuria in adolescent rat kidney independent of cyclooxygenase‐2

In patients, chronic treatment with lithium leads to renal microcysts and nephrogenic diabetes insipidus (NDI). It was hypothesized that renal cyclooxygenase‐2 (COX‐2) activity promotes microcyst formation and NDI. Kidney microcysts were induced in male adolescent rats by feeding dams with lithium (...

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Detalhes bibliográficos
Main Authors: Kjaersgaard, Gitte, Madsen, Kirsten, Marcussen, Niels, Jensen, Boye L.
Formato: Artigo
Idioma:Inglês
Publicado em: Wiley Periodicals, Inc. 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3967685/
https://ncbi.nlm.nih.gov/pubmed/24744881
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/phy2.202
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