The concomitant coronary vasodilator and positive inotropic actions of the nitroxyl donor Angeli's salt in the intact rat heart: contribution of soluble guanylyl cyclase-dependent and -independent mechanisms

BACKGROUND AND PURPOSE: The NO redox sibling nitroxyl (HNO) elicits soluble guanylyl cyclase (sGC)-dependent vasodilatation. HNO has high reactivity with thiols, which is attributed with HNO-enhanced left ventricular (LV) function. Here, we tested the hypothesis that the concomitant vasodilatation a...

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Main Authors: Chin, Kai Yee, Qin, Chengxue, Cao, Nga, Kemp-Harper, Barbara K, Woodman, Owen L, Ritchie, Rebecca H
格式: Artigo
語言:Inglês
出版: Blackwell Publishing Ltd 2014
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Research Paper
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3966751/
https://ncbi.nlm.nih.gov/pubmed/24372173
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.12568
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