PNPLA3 mediates hepatocyte triacylglycerol remodeling

The I148M substitution in patatin-like phospholipase domain containing 3 (PNPLA3(I148M)) determines a genetic form of nonalcoholic fatty liver disease. To elucidate the mode of PNPLA3 action in human hepatocytes, we studied effects of WT PNPLA3 (PNPLA3(WT)) and PNPLA3(I148M) on HuH7 cell lipidome af...

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Detalhes bibliográficos
Main Authors: Ruhanen, Hanna, Perttilä, Julia, Hölttä-Vuori, Maarit, Zhou, You, Yki-Järvinen, Hannele, Ikonen, Elina, Käkelä, Reijo, Olkkonen, Vesa M.
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society for Biochemistry and Molecular Biology 2014
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3966707/
https://ncbi.nlm.nih.gov/pubmed/24511104
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1194/jlr.M046607
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