TERT Promoter Mutations Occur Early in Urothelial Neoplasia and are Biomarkers of Early Disease and Disease Recurrence in Urine

Activating mutations occur in the promoter of the telomerase reverse transcriptase (TERT) gene in 66% of muscle-invasive urothelial carcinomas. To explore their role in bladder cancer development, and to assess their utility as urine markers for early detection, we sequenced the TERT promoter in 76...

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Detalhes bibliográficos
Main Authors: Kinde, Isaac, Munari, Enrico, Faraj, Sheila F., Hruban, Ralph H., Schoenberg, Mark, Bivalacqua, Trinity, Allaf, Mohamad, Springer, Simeon, Wang, Yuxuan, Diaz, Luis A., Kinzler, Kenneth W., Vogelstein, Bert, Papadopoulos, Nickolas, Netto, George J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3966102/
https://ncbi.nlm.nih.gov/pubmed/24121487
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-13-2498
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