FOXO4-Knockdown Suppresses Oxidative Stress-Induced Apoptosis of Early Pro-Angiogenic Cells and Augments Their Neovascularization Capacities in Ischemic Limbs

The effects of therapeutic angiogenesis by intramuscular injection of early pro-angiogenic cells (EPCs) to ischemic limbs are unsatisfactory. Oxidative stress in the ischemic limbs may accelerate apoptosis of injected EPCs, leading to less neovascularization. Forkhead transcription factor 4 (FOXO4)...

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Detalhes bibliográficos
Main Authors: Nakayoshi, Takaharu, Sasaki, Ken-ichiro, Kajimoto, Hidemi, Koiwaya, Hiroshi, Ohtsuka, Masanori, Ueno, Takafumi, Chibana, Hidetoshi, Itaya, Naoki, Sasaki, Masahiro, Yokoyama, Shinji, Fukumoto, Yoshihiro, Imaizumi, Tsutomu
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2014
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3963928/
https://ncbi.nlm.nih.gov/pubmed/24663349
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0092626
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