A Recombinant Novirhabdovirus Presenting at the Surface the E Glycoprotein from West Nile Virus (WNV) Is Immunogenic and Provides Partial Protection against Lethal WNV Challenge in BALB/c Mice

West Nile Virus (WNV) is a zoonotic mosquito-transmitted flavivirus that can infect and cause disease in mammals including humans. Our study aimed at developing a WNV vectored vaccine based on a fish Novirhabdovirus, the Viral Hemorrhagic Septicemia virus (VHSV). VHSV replicates at temperatures lowe...

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Détails bibliographiques
Auteurs principaux: Nzonza, Angella, Lecollinet, Sylvie, Chat, Sophie, Lowenski, Steeve, Mérour, Emilie, Biacchesi, Stéphane, Brémont, Michel
Format: Artigo
Langue:Inglês
Publié: Public Library of Science 2014
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3963854/
https://ncbi.nlm.nih.gov/pubmed/24663075
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0091766
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