Collagen degradation and neutrophilic infiltration: a vicious circle in inflammatory bowel disease

OBJECTIVE: Proline–glycine–proline (PGP) has been shown to have chemotactic effects on neutrophils via CXCR2 in several lung diseases. PGP is derived from collagen by the combined action of matrix metalloproteinase (MMP) 8 and/or MMP9 and prolyl endopeptidase (PE). We investigated the role of PGP in...

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Detalhes bibliográficos
Main Authors: Koelink, Pim J, Overbeek, Saskia A, Braber, Saskia, Morgan, Mary E, Henricks, Paul A J, Roda, Mojtaba Abdul, Verspaget, Hein W, Wolfkamp, Simone C, te Velde, Anje A, Jones, Caleb W, Jackson, Patricia L, Blalock, J Edwin, Sparidans, Rolf W, Kruijtzer, John A W, Garssen, Johan, Folkerts, Gert, Kraneveld, Aletta D
Formato: Artigo
Idioma:Inglês
Publicado em: BMJ Publishing Group 2014
Assuntos:
Inflammatory Bowel Disease
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3963538/
https://ncbi.nlm.nih.gov/pubmed/23525573
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/gutjnl-2012-303252
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