A Cre-versible approach identifies synthetic lethal interactions between MK2 and p53 in the DNA damage response in vivo

A fundamental limitation in devising new therapeutic strategies for killing cancer cells with DNA damaging agents is the need to identify synthetic lethal interactions between tumor-specific mutations and components of the DNA damage response (DDR) in vivo. The stress-activated p38MAPK/MK2 pathway i...

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Autores principales: Morandell, Sandra, Reinhardt, H. Christian, Cannell, Ian G., Kim, Jacob S., Ruf, Daniela M., Mitra, Tanya, Couvillon, Anthony D., Jacks, Tyler, Yaffe, Michael B.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2013
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3962842/
https://ncbi.nlm.nih.gov/pubmed/24239348
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2013.10.025
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