Chromatin-Bound IκBα Regulates a Subset of Polycomb Target Genes in Differentiation and Cancer

IκB proteins are the primary inhibitors of NF-κB. Here, we demonstrate that sumoylated and phosphorylated IκBα accumulates in the nucleus of keratinocytes and interacts with histones H2A and H4 at the regulatory region of HOX and IRX genes. Chromatin-bound IκBα modulates Polycomb recruitment and imp...

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Main Authors: Mulero, María Carmen, Ferres-Marco, Dolors, Islam, Abul, Margalef, Pol, Pecoraro, Matteo, Toll, Agustí, Drechsel, Nils, Charneco, Cristina, Davis, Shelly, Bellora, Nicolás, Gallardo, Fernando, López-Arribillaga, Erika, Asensio-Juan, Elena, Rodilla, Verónica, González, Jessica, Iglesias, Mar, Shih, Vincent, Albà, M. Mar, Di Croce, Luciano, Hoffmann, Alexander, Miyamoto, Shigeki, Villà-Freixa, Jordi, López-Bigas, Nuria, Keyes, William M., Domínguez, María, Bigas, Anna, Espinosa, Lluís
Format: Artigo
Sprog:Inglês
Udgivet: 2013
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3962677/
https://ncbi.nlm.nih.gov/pubmed/23850221
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccr.2013.06.003
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