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Cellular Uptake and Intracellular Trafficking of Oligonucleotides: Implications for Oligonucleotide Pharmacology

One of the major constraints on the therapeutic use of oligonucleotides is inefficient delivery to their sites of action in the cytosol or nucleus. Recently it has become evident that the pathways of cellular uptake and intracellular trafficking of oligonucleotides can strongly influence their pharm...

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Bibliographic Details
Main Authors: Juliano, R.L., Ming, Xin, Carver, Kyle, Laing, Brian
Format: Artigo
Language:Inglês
Published: Mary Ann Liebert, Inc. 2014
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3962645/
https://ncbi.nlm.nih.gov/pubmed/24383421
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/nat.2013.0463
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