High-density array analysis of DNA methylation in Tamoxifen-resistant breast cancer cell lines

Roughly two-thirds of all breast cancers are ERα-positive and can be treated with the antiestrogen, Tamoxifen, however resistance occurs in 33% of women who take the drug for more than 5 y. Aberrant DNA methylation, an epigenetic mechanism that alters gene expression in cancer, is thought to play a...

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Bibliografiske detaljer
Main Authors: Williams, Kristin E, Anderton, Douglas L, Lee, Maxwell P, Pentecost, Brian T, Arcaro, Kathleen F
Format: Artigo
Sprog:Inglês
Udgivet: Landes Bioscience 2014
Fag:
Research Paper
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3962540/
https://ncbi.nlm.nih.gov/pubmed/24225485
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/epi.27111
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