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Characterization of a Brg1 hypomorphic allele demonstrates that genetic and biochemical activity are tightly correlated

Mammalian SWI/SNF-related complexes are recruited to the promoters of numerous target genes, and the BRG1 catalytic subunit confers ATPase activity necessary to slide or evict nucleosomes and to regulate transcription. Based on gene-targeting experiments in mice, BRG1 is essential for early embryoni...

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Detalhes bibliográficos
Main Authors: Chandler, Ronald L, Zhang, Ying, Magnuson, Terry, Bultman, Scott J
Formato: Artigo
Idioma:Inglês
Publicado em: Landes Bioscience 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3962535/
https://ncbi.nlm.nih.gov/pubmed/24172864
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/epi.26879
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