Widespread FRA1-Dependent Control of Mesenchymal Transdifferentiation Programs in Colorectal Cancer Cells

Tumor invasion and metastasis involves complex remodeling of gene expression programs governing epithelial homeostasis. Mutational activation of the RAS-ERK is a frequent occurrence in many cancers and has been shown to drive overexpression of the AP-1 family transcription factor FRA1, a potent regu...

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Detalhes bibliográficos
Main Authors: Diesch, Jeannine, Sanij, Elaine, Gilan, Omer, Love, Christopher, Tran, Hoanh, Fleming, Nicholas I., Ellul, Jason, Amalia, Marcia, Haviv, Izhak, Pearson, Richard B., Tulchinsky, Eugene, Mariadason, John M., Sieber, Oliver M., Hannan, Ross D., Dhillon, Amardeep S.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2014
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3962334/
https://ncbi.nlm.nih.gov/pubmed/24658684
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0088950
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