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Central Cavity of Fructose-1,6-bisphosphatase and the Evolution of AMP/Fructose 2,6-bisphosphate Synergism in Eukaryotic Organisms

The effects of AMP and fructose 2,6-bisphosphate (Fru-2,6-P(2)) on porcine fructose-1,6-bisphosphatase (pFBPase) and Escherichia coli FBPase (eFBPase) differ in three respects. AMP/Fru-2,6-P(2) synergism in pFBPase is absent in eFBPase. Fru-2,6-P(2) induces a 13° subunit pair rotation in pFBPase but...

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Detalhes bibliográficos
Main Authors: Gao, Yang, Shen, Lu, Honzatko, Richard B.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3961670/
https://ncbi.nlm.nih.gov/pubmed/24436333
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.548586
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