Hepatitis B Virus Infection and Immunopathogenesis in a Humanized Mouse Model: Induction of Human-Specific Liver Fibrosis and M2-Like Macrophages

The mechanisms of chronic HBV infection and immunopathogenesis are poorly understood due to a lack of a robust small animal model. Here we report the development of a humanized mouse model with both human immune system and human liver cells by reconstituting the immunodeficient A2/NSG (NOD.Cg-Prkdc(...

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Hauptverfasser: Bility, Moses T., Cheng, Liang, Zhang, Zheng, Luan, Yan, Li, Feng, Chi, Liqun, Zhang, Liguo, Tu, Zhengkun, Gao, Yanhang, Fu, Yangxin, Niu, Junqi, Wang, Fusheng, Su, Lishan
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2014
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Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3961374/
https://ncbi.nlm.nih.gov/pubmed/24651854
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1004032
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