Relaxed Rotational and Scrunching Changes in P266L Mutant of T7 RNA Polymerase Reduce Short Abortive RNAs while Delaying Transition into Elongation

Abortive cycling is a universal feature of transcription initiation catalyzed by DNA-dependent RNA polymerases (RNAP). In bacteriophage T7 RNAP, mutation of proline 266 to leucine (P266L) in the C-linker region connecting the N-terminal promoter binding domain with the C-terminal catalytic domain dr...

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Autores principales: Tang, Guo-Qing, Nandakumar, Divya, Bandwar, Rajiv P., Lee, Kyung Suk, Roy, Rahul, Ha, Taekjip, Patel, Smita S.
Formato: Artigo
Lenguaje:Inglês
Publicado: Public Library of Science 2014
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Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3961267/
https://ncbi.nlm.nih.gov/pubmed/24651161
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0091859
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