ABCB1 haplotypes are associated with P-gp activity and affect a major molecular response in chronic myeloid leukemia patients treated with a standard dose of imatinib

Despite the high efficacy of imatinib mesylate (IM) treatment for chronic myeloid leukemia (CML) patients, some individuals develop resistance due to impaired bioavailability. It has been previously demonstrated that the haplotypes for ATP-binding cassette subfamily B member 1 (ABCB1)with c.1236C>...

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Autors principals: VIVONA, DOUGLAS, LIMA, LUCIENE TEREZINA, RODRIGUES, ALICE CRISTINA, BUENO, CAROLINA TOSIN, ALCANTARA, GREYCE KELLY STEINHORST, BARROS, LUIZA SALDANHA RIBEIRO, DE MORAES HUNGRIA, VANIA TIESTSCHE, CHIATTONE, CARLOS SÉRGIO, DE LOURDES LOPES FERRARI CHAUFFAILLE, MARIA, GUERRA-SHINOHARA, ELVIRA MARIA
Format: Artigo
Idioma:Inglês
Publicat: D.A. Spandidos 2014
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Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3961201/
https://ncbi.nlm.nih.gov/pubmed/24660038
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3892/ol.2014.1857
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