Focal amplification of the androgen receptor gene in hormone-naive human prostate cancer

BACKGROUND: Androgen receptor (AR)-gene amplification, found in 20–30% of castration-resistant prostate cancer (CRPCa) is proposed to develop as a consequence of hormone-deprivation therapy and be a prime cause of treatment failure. Here we investigate AR-gene amplification in cancers before hormone...

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Autors principals: Merson, S, Yang, Z H, Brewer, D, Olmos, D, Eichholz, A, McCarthy, F, Fisher, G, Kovacs, G, Berney, D M, Foster, C S, Møller, H, Scardino, P, Cuzick, J, Cooper, C S, Clark, J P
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 2014
Matèries:
Genetics and Genomics
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3960602/
https://ncbi.nlm.nih.gov/pubmed/24481405
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/bjc.2014.13
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