A Sensory Neuron-expressed Interleukin-31 Receptor Mediates T helper Cell-dependent Itch: Involvement of TRPV1 and TRPA1

BACKGROUND: Although the cytokine, interleukin-31 (IL-31), has been implicated in inflammatory and lymphoma-associated itch, the cellular basis for its pruritic action is yet unclear. OBJECTIVE: To determine whether immune cell-derived IL-31 directly stimulates sensory neurons, and to identify the m...

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Autors principals: Cevikbas, Ferda, Wang, Xidao, Akiyama, Tasuku, Kempkes, Cordula, Savinko, Terhi, Antal, Attila, Kukova, Gabriela, Buhl, Timo, Ikoma, Akihiko, Buddenkotte, Joerg, Soumelis, Vassili, Feld, Micha, Alenius, Harri, Dillon, Stacey R., Carstens, Earl, Homey, Bernhard, Basbaum, Allan, Steinhoff, Martin
Format: Artigo
Idioma:Inglês
Publicat: 2013
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3960328/
https://ncbi.nlm.nih.gov/pubmed/24373353
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jaci.2013.10.048
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